N-(2-((tert-butyldimethylsilyl)oxy)ethyl)propan-2-amine → HCID 178457472, compound

HRID 2169530Notes

Reaction equation

HRID 2169530 reaction equation
[Si](OCCN(C)C(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N=1)=O)(C(C)(C)C)(C)C.[CH2:46]([O:53][C:54]1[C:55]([C:77]([OH:79])=O)=[N:56][C:57]([CH2:61][C:62]2([C:67]3[C:76]4[C:71](=[CH:72][CH:73]=[CH:74][CH:75]=4)[CH:70]=[CH:69][CH:68]=3)[CH2:66][CH2:65][CH2:64][CH2:63]2)=[N:58][C:59]=1[OH:60])[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1.[Si:80]([O:87][CH2:88][CH2:89][NH:90][CH:91]([CH3:93])[CH3:92])([C:83]([CH3:86])([CH3:85])[CH3:84])([CH3:82])[CH3:81]>>[CH2:46]([O:53][C:54]1[C:55]([C:77]([N:90]([CH2:89][CH2:88][O:87][Si:80]([C:83]([CH3:85])([CH3:84])[CH3:86])([CH3:81])[CH3:82])[CH:91]([CH3:92])[CH3:93])=[O:79])=[N:56][C:57]([CH2:61][C:62]2([C:67]3[C:76]4[C:71](=[CH:72][CH:73]=[CH:74][CH:75]=4)[CH:70]=[CH:69][CH:68]=3)[CH2:66][CH2:65][CH2:64][CH2:63]2)=[N:58][C:59]=1[OH:60])[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1

Participants

4

Reactant 3

HCID 57917054N-(2-((tert-butyldimethylsilyl)oxy)ethyl)propan-2-amineHCID 178484768HCID 178484768, compoundHCID 178524864HCID 178524864, compound

Product 1

HCID 178457472HCID 178457472, compound

Procedure

This compound was prepared by following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (350) from 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (345) and [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-isopropyl-amine (8b).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-f5cfe9f9f7e34352992b9ad94bf6c9e4
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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