HRID2169530

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57917054

未命名化合物

结构：CN(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178484768

未命名化合物

结构：O=C(O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178524864

未命名化合物

PRODUCTS

生成物

结构：CC(C)N(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178457472

未命名化合物

PROCEDURE

实验过程

This compound was prepared by following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (350) from 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (345) and [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-isopropyl-amine (8b).

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f5cfe9f9f7e34352992b9ad94bf6c9e4
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

[Si](OCCN(C)C(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N=1)=O)(C(C)(C)C)(C)C.[CH2:46]([O:53][C:54]1[C:55]([C:77]([OH:79])=O)=[N:56][C:57]([CH2:61][C:62]2([C:67]3[C:76]4[C:71](=[CH:72][CH:73]=[CH:74][CH:75]=4)[CH:70]=[CH:69][CH:68]=3)[CH2:66][CH2:65][CH2:64][CH2:63]2)=[N:58][C:59]=1[OH:60])[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1.[Si:80]([O:87][CH2:88][CH2:89][NH:90][CH:91]([CH3:93])[CH3:92])([C:83]([CH3:86])([CH3:85])[CH3:84])([CH3:82])[CH3:81]>>[CH2:46]([O:53][C:54]1[C:55]([C:77]([N:90]([CH2:89][CH2:88][O:87][Si:80]([C:83]([CH3:85])([CH3:84])[CH3:86])([CH3:81])[CH3:82])[CH:91]([CH3:92])[CH3:93])=[O:79])=[N:56][C:57]([CH2:61][C:62]2([C:67]3[C:76]4[C:71](=[CH:72][CH:73]=[CH:74][CH:75]=4)[CH:70]=[CH:69][CH:68]=3)[CH2:66][CH2:65][CH2:64][CH2:63]2)=[N:58][C:59]=1[OH:60])[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1