HRID2169531

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)N(CCO[Si](C)(C)C(C)(C)C)C(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178457472

未命名化合物

结构：CN(CCO)C(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178484637

未命名化合物

PRODUCTS

生成物

结构：CC(C)N(CCO)C(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178457436

未命名化合物

PROCEDURE

实验过程

This compound was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (2-hydroxyethyl)-methyl-amide (351) from 5-(benzyloxy)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6-hydroxy-N-isopropyl-2-((1-(naphthalen-1-yl)cyclopentyl)methyl)pyrimidine-4-carboxamide (510).

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-55cc3745f4ba49648abedb481b63b081
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

OCCN(C)C(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N=1)=O.[CH2:39]([O:46][C:47]1[C:48]([C:70]([N:72]([CH2:76][CH2:77][O:78][Si](C(C)(C)C)(C)C)[CH:73]([CH3:75])[CH3:74])=[O:71])=[N:49][C:50]([CH2:54][C:55]2([C:60]3[C:69]4[C:64](=[CH:65][CH:66]=[CH:67][CH:68]=4)[CH:63]=[CH:62][CH:61]=3)[CH2:59][CH2:58][CH2:57][CH2:56]2)=[N:51][C:52]=1[OH:53])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>>[CH2:39]([O:46][C:47]1[C:48]([C:70]([N:72]([CH2:76][CH2:77][OH:78])[CH:73]([CH3:75])[CH3:74])=[O:71])=[N:49][C:50]([CH2:54][C:55]2([C:60]3[C:69]4[C:64](=[CH:65][CH:66]=[CH:67][CH:68]=4)[CH:63]=[CH:62][CH:61]=3)[CH2:56][CH2:57][CH2:58][CH2:59]2)=[N:51][C:52]=1[OH:53])[C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1