9-benzyloxy-2-methyl-6-(1-naphthalen-1-yl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione → 9-(Benzyloxy)-2-isopropyl-6-((1-(naphthalen-1-yl)cyclopentyl)methyl)-3,4-dihydro-1H-pyrazino[1,2-c]pyrimidine-1,8(2H)-dione

HRID 2169532Notes

Reaction equation

HRID 2169532 reaction equation
C(OC1C(=O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N2CCN(C)C(=O)C=12)C1C=CC=CC=1.[CH2:38]([O:45][C:46]1[C:47]([C:69]([N:71]([CH2:75][CH2:76]O)[CH:72]([CH3:74])[CH3:73])=[O:70])=[N:48][C:49]([CH2:53][C:54]2([C:59]3[C:68]4[C:63](=[CH:64][CH:65]=[CH:66][CH:67]=4)[CH:62]=[CH:61][CH:60]=3)[CH2:58][CH2:57][CH2:56][CH2:55]2)=[N:50][C:51]=1[OH:52])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[CH2:38]([O:45][C:46]1[C:51](=[O:52])[N:50]=[C:49]([CH2:53][C:54]2([C:59]3[C:68]4[C:63](=[CH:64][CH:65]=[CH:66][CH:67]=4)[CH:62]=[CH:61][CH:60]=3)[CH2:55][CH2:56][CH2:57][CH2:58]2)[N:48]2[CH2:76][CH2:75][N:71]([CH:72]([CH3:73])[CH3:74])[C:69](=[O:70])[C:47]=12)[C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1

Participants

3

Reactant 2

HCID 867260169-benzyloxy-2-methyl-6-(1-naphthalen-1-yl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dioneHCID 178457436HCID 178457436, compound

Product 1

HCID 867261549-(Benzyloxy)-2-isopropyl-6-((1-(naphthalen-1-yl)cyclopentyl)methyl)-3,4-dihydro-1H-pyrazino[1,2-c]pyrimidine-1,8(2H)-dione

Procedure

This compound was prepared following the same method as described for pure 9-Benzyloxy-2-methyl-6-(1-naphthalen-1-yl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (352) from 5-(benzyloxy)-6-hydroxy-N-(2-hydroxyethyl)-N-isopropyl-2-((1-(naphthalen-1-yl)cyclopentyl)methyl)pyrimidine-4-carboxamide (511).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-a86e10d1fba04663b3e0d1fa084ade46
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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