HRID2169534

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID529218

Ethanamine, mono-TMS

C8H21NOSi

结构：CC(C)(C)[Si](C)(C)OCCNC(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178455268

未命名化合物

结构：O=C(O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1

HCID178524871

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OCCNC(=O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1

HCID178455277

未命名化合物

PROCEDURE

实验过程

This compound was prepared by following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-amide (346) from 5-benzyloxy-2-[1-(4-chlorophenyl)-cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (324) and 2-(tert-butyl-dimethylsilanyloxy)-ethylamine (8c).

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4ddf2f03291e4c27a21c8a48750ff06c
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

[Si:1]([O:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[C:19]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:18]([OH:28])[N:17]=[C:16]([CH2:29][C:30]2([C:35]3[C:44]4[C:39](=CC=CC=4)[CH:38]=[CH:37][CH:36]=3)[CH2:34][CH2:33][CH2:32][CH2:31]2)[N:15]=1)=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].C(OC1C(C(O)=O)=NC(CC2(C3C=CC([Cl:72])=CC=3)CCCC2)=NC=1O)C1C=CC=CC=1.[Si](OCCN)(C(C)(C)C)(C)C>>[CH2:21]([O:20][C:19]1[C:14]([C:12]([NH:11][CH2:10][CH2:9][O:8][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2])=[O:13])=[N:15][C:16]([CH2:29][C:30]2([C:35]3[CH:44]=[CH:39][C:38]([Cl:72])=[CH:37][CH:36]=3)[CH2:34][CH2:33][CH2:32][CH2:31]2)=[N:17][C:18]=1[OH:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1