HRID2169535

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)OCCNC(=O)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1

HCID178455277

未命名化合物

结构：O=C(NCCO)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178523453

未命名化合物

PRODUCTS

生成物

结构：O=C(NCCO)c1nc(CC2(c3ccc(Cl)cc3)CCCC2)nc(O)c1OCc1ccccc1

HCID178523454

未命名化合物

PROCEDURE

实验过程

This compound was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (2-hydroxyethyl)-amide (347) from 5-(benzyloxy)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-((1-(4-chlorophenyl)cyclopentyl)methyl)-6-hydroxypyrimidine-4-carboxamide (514).

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8b95e64f56a94eeebdde18740b66b600
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

OCCNC(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N=1)=O.[CH2:38]([O:45][C:46]1[C:47]([C:66]([NH:68][CH2:69][CH2:70][O:71][Si](C(C)(C)C)(C)C)=[O:67])=[N:48][C:49]([CH2:53][C:54]2([C:59]3[CH:64]=[CH:63][C:62]([Cl:65])=[CH:61][CH:60]=3)[CH2:58][CH2:57][CH2:56][CH2:55]2)=[N:50][C:51]=1[OH:52])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[CH2:38]([O:45][C:46]1[C:47]([C:66]([NH:68][CH2:69][CH2:70][OH:71])=[O:67])=[N:48][C:49]([CH2:53][C:54]2([C:59]3[CH:60]=[CH:61][C:62]([Cl:65])=[CH:63][CH:64]=3)[CH2:55][CH2:56][CH2:57][CH2:58]2)=[N:50][C:51]=1[OH:52])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1