HCID 178455277, compound → HCID 178523454, compound

HRID 2169535Notes

Reaction equation

HRID 2169535 reaction equation
OCCNC(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N=1)=O.[CH2:38]([O:45][C:46]1[C:47]([C:66]([NH:68][CH2:69][CH2:70][O:71][Si](C(C)(C)C)(C)C)=[O:67])=[N:48][C:49]([CH2:53][C:54]2([C:59]3[CH:64]=[CH:63][C:62]([Cl:65])=[CH:61][CH:60]=3)[CH2:58][CH2:57][CH2:56][CH2:55]2)=[N:50][C:51]=1[OH:52])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[CH2:38]([O:45][C:46]1[C:47]([C:66]([NH:68][CH2:69][CH2:70][OH:71])=[O:67])=[N:48][C:49]([CH2:53][C:54]2([C:59]3[CH:60]=[CH:61][C:62]([Cl:65])=[CH:63][CH:64]=3)[CH2:55][CH2:56][CH2:57][CH2:58]2)=[N:50][C:51]=1[OH:52])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1

Participants

3

Reactant 2

HCID 178455277HCID 178455277, compoundHCID 178523453HCID 178523453, compound

Product 1

HCID 178523454HCID 178523454, compound

Procedure

This compound was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (2-hydroxyethyl)-amide (347) from 5-(benzyloxy)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-2-((1-(4-chlorophenyl)cyclopentyl)methyl)-6-hydroxypyrimidine-4-carboxamide (514).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-8b95e64f56a94eeebdde18740b66b600
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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