9-hydroxy-6-(1-naphthalen-1-yl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione → 6-((1-(4-Chlorophenyl)cyclopentyl)methyl)-9-hydroxy-3,4-dihydro-1H-pyrazino[1,2-c]pyrimidine-1,8(2H)-dione

HRID 2169537Notes

Reaction equation

HRID 2169537 reaction equation
OC1C(=O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N2CCNC(=O)C=12.C([O:37][C:38]1[C:43](=[O:44])[N:42]=[C:41]([CH2:45][C:46]2([C:51]3[CH:56]=[CH:55][C:54]([Cl:57])=[CH:53][CH:52]=3)[CH2:50][CH2:49][CH2:48][CH2:47]2)[N:40]2[CH2:58][CH2:59][NH:60][C:61](=[O:62])[C:39]=12)C1C=CC=CC=1>>[Cl:57][C:54]1[CH:55]=[CH:56][C:51]([C:46]2([CH2:45][C:41]3[N:40]4[CH2:58][CH2:59][NH:60][C:61](=[O:62])[C:39]4=[C:38]([OH:37])[C:43](=[O:44])[N:42]=3)[CH2:50][CH2:49][CH2:48][CH2:47]2)=[CH:52][CH:53]=1

Participants

3

Reactant 2

HCID 867260189-hydroxy-6-(1-naphthalen-1-yl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dioneHCID 867261589-(Benzyloxy)-6-((1-(4-chlorophenyl)cyclopentyl)methyl)-3,4-dihydro-1H-pyrazino[1,2-c]pyrimidine-1,8(2H)-dione

Product 1

HCID 867261596-((1-(4-Chlorophenyl)cyclopentyl)methyl)-9-hydroxy-3,4-dihydro-1H-pyrazino[1,2-c]pyrimidine-1,8(2H)-dione

Procedure

This compound was prepared following the same method as described for pure 9-hydroxy-6-(1-naphthalen-1-yl-cyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (349) from 9-(benzyloxy)-6-((1-(4-chlorophenyl)cyclopentyl)methyl)-3,4-dihydro-1H-pyrazino[1,2-c]pyrimidine-1,8(2H)-dione (517).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-f4264678274046f4af9b8af43678e436
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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