Methyl N-(triethylammoniosulfonyl)carbamate → (S)-tert-Butyl 4-(1-cyano-2-(4'-cyanobiphenyl-4-yl)ethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate

Participants

Reaction Steps

(S)-tert-Butyl 4-(1-amino-3-(3′-cyano-4′-fluorobiphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 22, step (i), 366 mg) in dichloromethane (5 mL) was treated with Burgess' reagent (205 mg) and the mixture was stirred at room temperature for 18 h. The reaction mixture was evaporated to afford the sub-titled compound as a crude mixture (336 mg).

Provenance & Evidence