Sodium t-butoxide → HCID 86670106, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to PREPARATION x9 using 2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (PREPARATION x2, 75 mg, 0.331 mmol) in DMSO (2 mL) followed by sodium tert-butoxide (35.0 mg, 0.364 mmol) and 2-(chloromethyl)-5-cyclopropyl-1,3,4-oxadiazole (68.2 mg, 0.430 mmol). 1H NMR (400 MHz, DMSO-d6) δ 0.92-1.00 (m, 2 H), 1.07-1.16 (m, 2 H), 2.14-2.25 (m, 1 H), 2.92-3.03 (m, 1 H), 3.03-3.11 (m, 1 H), 3.11-3.20 (m, 1 H), 3.34-3.51 (m, 1 H), 3.53-3.58 (m, 1 H), 3.59-3.72 (m, 1 H), 3.85-4.00 (m, 2 H), 4.20-4.29 (m, 1 H), 4.53-4.63 (m, 1 H), 4.79-4.88 (m, 1 H), 7.56 (s, 1 H). ESI-MS m/z [M+H]+ calc'd for C15H17ClN6O2, 348.11; found 348.2.

Provenance & Evidence