Methyl 4-oxobutyrate → HCID 86670134, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to PREPARATION x63 using (R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (PREPARATION x2, 250 mg, 1.103 mmol), methyl 4-oxobutanoate (128 mg, 1.103 mmol), titanium(IV) chloride in CH2Cl2 (1M, 1.654 mL, 1.654 mmol) and sodium triacetoxyhydroborate (514 mg, 2.427 mmol) in CH2Cl2 (8 mL) (164 mg, 46%). ESI-MS m/z [M+H]+ calc'd for C14H19ClN4O3, 327.12; found 327.2.

Provenance & Evidence