HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (4,4-dimethyl-1-oxopentan-3-yl)carbamate → HCID 86670143, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (4,4-dimethyl-1-oxopentan-3-yl)carbamate | HCID 17039462 | — |
| Reactant | (R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine | HCID 86670088 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Sodium | HCID 5360545 | — |
| Product | HCID 86670143 | HCID 86670143 | — |
Reaction Steps
The title compound was prepared in a manner similar to PREPARATION x63 using (R)-2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (PREPARATION x2, 115 mg, 0.507 mmol), tert-butyl 4,4-dimethyl-1-oxopentan-3-ylcarbamate (116 mg, 0.507 mmol), titanium(IV) chloride in CH2Cl2 (1M, 0.761 mL, 0.761 mmol) and sodium triacetoxyhydroborate (237 mg, 1.116 mmol) in CH2Cl2 (5 mL) (53 mg, 24%). ESI-MS m/z [M+H]+ calc'd for C21H34ClN5O3, 440.24; found 440.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045496B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-7a215ad2c2e845fdbe49fe78db2ee709 |
| Source note | uspto-grants-2015_06 |