HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-4-boronic acid → HCID 68197777, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-4-boronic acid | HCID 2763173 | — |
| Reactant | HCID 86670143 | HCID 86670143 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 68197777 | HCID 68197777 | — |
Reaction Steps
The title compound was prepared in a manner similar to Example 2 using tert-butyl (1-((R)-2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)-4,4-dimethylpentan-3-yl)carbamate (PREPARATION x77, 53 mg, 0.120 mmol), 1H-indol-4-ylboronic acid (38.8 mg, 0.241 mmol) and PdCl2(dppf) (4.41 mg, 0.006 mmol) in dioxane (2 mL) and aqueous saturated NaHCO3 (0.4 mL) (19 mg, 30%). ESI-MS m/z [M+H]+ calc'd for C29H40N6O3, 521.32; found 521.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045496B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-471591dc9423429a97412a0d609340c1 |
| Source note | uspto-grants-2015_06 |