Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

A TFA salt of the title compound was prepared in a manner similar to EXAMPLE 8 using tert-butyl 3-(5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)-7-methoxy-1H-indole-1-carboxylate (60 mg, 0.137 mmol) in CH2Cl2 and TFA. 1H NMR (400 MHz, DMSO-d6) δ 2.92-3.05 (m, 1 H), 3.27-3.30 (m, 1 H), 3.53-3.66 (m, 1 H), 3.76-3.90 (m, 1 H), 3.91-3.98 (m, 5 H), 3.97-4.06 (m, 1 H), 4.08-4.18 (m, 1 H), 4.68-4.84 (m, 1 H), 6.33-6.45 (br s, 1 H), 6.79-6.87 (m, 1 H), 7.09-7.20 (m, 1 H), 7.38-7.46 (m, 1 H), 7.80-7.89 (m, 1 H), 8.15-8.23 (m, 1 H), 12.18-12.29 (m, 1 H). ESI-MS m/z [M+H]+ calc'd for C18H19N5O2S, 338.15; found 338.4.

Provenance & Evidence