HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68194963, compound → HCID 136209611, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68194963 | HCID 68194963 | — |
| Reactant | HCID 86670087 | HCID 86670087 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 136209611 | HCID 136209611 | — |
Reaction Steps
The title compound was prepared in a manner similar to EXAMPLE 1 using 2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (PREPARATION x2, 50 mg, 0.221 mmol), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-ol (30 mg, 0.116 mmol), and PdCl2(dppf) (12.91 mg, 0.018 mmol) in dioxane (2 mL) and aqueous saturated NaHCO3 (0.4 mL). 1H NMR (400 MHz, DMSO-d6) δ 2.95-3.03 (m, 2 H), 3.20-3.30 (m, 3 H), 3.77-3.83 (m, 2 H), 3.88-3.95 (m, 1 H), 4.00-4.08 (m, 1 H), 4.36-4.45 (m, 1 H), 6.01-6.15 (m, 1 H), 6.78-6.85 (m, 1 H), 7.18-7.26 (m, 1 H), 7.62-7.68 (m, 1 H), 7.74-7.80 (m, 1 H), 10.23-10.52 (m, 1 H), 12.27-12.56 (m, 1 H). ESI-MS m/z [M+H]+ calc'd for C17H17N5O2, 323.14; found 324.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045496B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-d7ef6d18ce3b43e096e6a4a413ec65ca |
| Source note | uspto-grants-2015_06 |