(2-Methoxypyridin-4-yl)boronic acid → HCID 60197875, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to EXAMPLE 1 using 2-methoxypyridin-4-ylboronic acid (270 mg, 1.765 mmol), 2-chloro-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine (PREPARATION x2, 200 mg, 0.882 mmol), and PdCl2(dppf) (51.7 mg, 0.071 mmol) in dioxane (5 mL) and aqueous saturated NaHCO3 (1 mL). 1H NMR (400 MHz, DMSO-d6) δ 3.01-3.23 (m, 7 H), 3.89 (m, 3 H), 3.92-3.97 (m, 1 H), 3.99-4.06 (m, 1 H), 4.53-4.62 (m, 1 H), 7.47 (d, J=0.76 Hz, 1 H), 7.62 (s, 1 H), 7.68 (dd, J=5.31, 1.52 Hz, 1 H), 8.24 (d, J=5.56 Hz, 1 H). ESI-MS m/z [M+H]+ calc'd for C15H17N5O2, 299.14; found 300.2.

Provenance & Evidence