1H-Indole-4-boronic acid → HCID 60196655, compound

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Reaction Steps

The title compound was prepared in a manner similar to EXAMPLE 3 using 3-((2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)methyl)benzonitrile (PREPARATION x14, 59 mg, 0.173 mmol), PdCl2(dppf) (6.32 mg, 8.63 μmol) and 1H-indol-4-ylboronic acid (55.6 mg, 0.345 mmol) in dioxane (2 mL) and aqueous saturated NaHCO3 (0.4 mL). 1H NMR (400 MHz, DMSO-d6) δ 3.16-3.32 (m, 3 H), 3.55-3.66 (m, 2 H), 3.92-4.06 (m, 2 H), 4.07-4.16 (m, 1 H), 4.57-4.78 (m, 3 H), 6.96-7.07 (m, 1 H), 7.20-7.32 (m, 1 H), 7.40-7.48 (m, 1 H), 7.52-7.69 (m, 4 H), 7.71-7.84 (m, 2 H), 7.85-7.93 (m, 1 H), 11.45-11.59 (m, 1 H). ESI-MS m/z [M+H]+ calc'd for C25H22N6O, 423.19; found 423.3.

Provenance & Evidence