1H-Indole-4-boronic acid → HCID 60196657, compound

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Reaction Steps

The title compound was prepared in a manner similar to EXAMPLE 3 using 3-((2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-5(6H)-yl)methyl)-4-fluorobenzonitrile (PREPARATION x15, 73 mg, 0.203 mmol), PdCl2(dppf) (7.42 mg, 10.14 μmol) and 1H-indol-4-ylboronic acid (65.3 mg, 0.406 mmol) in dioxane (2 mL) and aqueous saturated NaHCO3 (0.4 mL). 1H NMR (400 MHz, DMSO-d6) δ 3.18-3.30 (m, 3 H), 3.46-3.53 (m, 1 H), 3.56-3.67 (m, 1 H), 3.92-4.05 (m, 2 H), 4.07-4.17 (m, 1 H), 4.58-4.78 (m, 3 H), 6.98-7.08 (m, 1 H), 7.22-7.32 (m, 1 H), 7.48-7.60 (m, 3 H), 7.60-7.70 (m, 2 H), 7.89-8.03 (m, 2 H), 11.47-11.58 (m, 1 H). ESI-MS m/z [M+H]+ calc'd for C25H21FN6O, 441.18; found 441.3.

Provenance & Evidence