HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2169706Generated: November 1, 2026
Hydrochloric Acid → 6-(4-Amino-phenoxy)hexanoic acid hydrochloride
https://huagongshe.com/reaction/2169706
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-(4-Acetylaminophenoxy)-hexanoic acid methyl ester | HCID 49764491 | — |
| Product | 6-(4-Amino-phenoxy)hexanoic acid hydrochloride | HCID 66811347 | 55.6% |
Reaction Steps
A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | USRE045548E1 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-7dd5648f0a1340bb865a9badd013dae3 |
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| Source note | uspto-grants-2015_06 |
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