反应详情

A solution of methyl 4-bromo-2-(bromomethyl)benzoate (410 mmol) in MeNH2/MeOH (1500 mL) was heated to reflux and stirred for 18 h. The reaction mixture was concentrated and the residue was purified by chromatography on silica eluting with petroleum ether/ethyl acetate (6:1 to 3:1) to afford the sub-titled compound (48.5 g).

1. temperatureto reflux
2. concentrationThe reaction mixture was concentrated
3. customthe residue was purified by chromatography on silica eluting with petroleum ether/ethyl acetate (6:1 to 3:1)