Sodium Methoxide → HCID 89876399, compound

Participants

Reaction Steps

6-bromo-4,5-dichloro-2-methyl-pyridazin-3-one (1.5 g, 5.8 mmol) is dissolved in 1,4-dioxane (150 ml). Sodium methoxide (1.5 ml, 25 mass % methanolic solution, 6.4 mmol) is added dropwise and the reaction stirred for 2 h. The mixture is concentrated to a volume of 50 ml then diluted with 50 ml EtOAc. It is washed with 2×35 ml aqueous saturated brine. The organic layer is dried thoroughly over sodium sulfate, filtered and concentrated in vacuo. The crude residue so obtained was purified by flash chromatography (silica gel, eluant a 0-10% EtOAc in Isohexane gradient) to afford 6-bromo-5-chloro-4-methoxy-2-methyl-pyridazin-3-one (960 mg) as a white solid (65% yield).

Provenance & Evidence