Water → HCID 117833194, compound

Participants

Reaction Steps

To a stirred solution of 4-(2,3-dichloroindol-1-yl)-6-isopropenyl-5-methoxy-2-methyl-pyridazin-3-one (355 mg, 0.975 mmol) in ethanol (5.0 mL) is added ammonium formate (1.24 g) and 20% palladium hydroxide on carbon, (50% water by weight, 273 mg, 0194 mmol). The resulting reaction mixture is stirred at ambient temperature for 1 h and then heated to 60° C. for 30 min. The resulting reaction mixture is allowed to cool and then filtered through celite, washing with ethanol and concentrated in vacuo. The resulting crude yellow solid was 4-indol-1-yl-6-isopropyl-5-methoxy-2-methyl-pyridazin-3-one (253 mg, 0.851 mmol, 87%), which was used without further purification.

Provenance & Evidence