Sodium borohydride → HCID 89876292, compound

Participants

Reaction Steps

To a stirred solution of 6-acetyl-4-(2,3-dichloroindol-1-yl)-5-methoxy-2-methyl-pyridazin-3-one (500 mg, 1.37 mmol) in ethanol (1 mL) at 0° C. is added sodium borohydride (79 mg, 2.05 mmol). After stirring for 20 min, the reaction is quenched with water (10 mL), then concentrated under reduced pressure to remove most of the ethanol. The aqueous solution is then extracted with Et2O (20 mL×2), then concentrated under reduced pressure to give the desired product 4-(2,3-dichloroindol-1-yl)-6-(1-hydroxyethyl)-5-methoxy-2-methyl-pyridazin-3-one (379 mg, 1.03 mmol, 75%) as a white solid.

Provenance & Evidence