Methyl N-(triethylammoniosulfonyl)carbamate → HCID 86675095, compound

Participants

Reaction Steps

Burgess' reagent (348 mg) was added to (S)-tert-butyl 1-(1-amino-3-(4-(6-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)cyclohexylcarbamate (Example 32, step (iii), 391 mg) in dichloromethane (25 mL) at 20° C. under nitrogen. The resulting solution was stirred at room temperature for 16 h. The reaction mixture was diluted with dichloromethane, and washed with water. The organic layer was dried over magnesium sulfate, filtered and evaporated to afford crude product. The crude product was purified by chromatography on silica eluting with methanol/ethyl acetate (10:90 to 40:60) to afford the sub-titled compound (360 mg).

Provenance & Evidence