Ammonia → Ethyl 4-amino-7-fluoroquinoline-3-carboxylate

HRID 2169835Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14].[NH3:18]>>[NH2:18][C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14]

Participants

Reactant 2

HCID 222Ammonia

HCID 14219731Ethyl 4-chloro-7-fluoroquinoline-3-carboxylate

Product 1

HCID 49758107Ethyl 4-amino-7-fluoroquinoline-3-carboxylate

Procedure

Prepared as in Example 1a from ethyl 4-chloro-7-fluoroquinoline-3-carboxylate (Example 9b) and ammonia as an off white solid (99%). MS 235 (MH+).

Sources & evidence

ORD record: ord-247df5812dd74728abe987d6b0ba8f95
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09049878B2

Reaction notes

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