2-Amino-6-fluorobenzonitrile → N-(4-(3-amino-2-cyanophenoxy)cyclohexyl)isobutyramide

HRID 2169895Notes

Reaction equation

HRID 2169895 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[CH2:4][CH2:3]1.[NH2:14][C:15]1[CH:22]=[CH:21][CH:20]=[C:19](F)[C:16]=1[C:17]#[N:18]>>[NH2:14][C:15]1[C:16]([C:17]#[N:18])=[C:19]([CH:20]=[CH:21][CH:22]=1)[O:1][CH:2]1[CH2:3][CH2:4][CH:5]([NH:8][C:9](=[O:13])[CH:10]([CH3:11])[CH3:12])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 21533977N-(4-Hydroxycyclohexyl)isobutyramide

Product 1

HCID 66745656N-(4-(3-amino-2-cyanophenoxy)cyclohexyl)isobutyramide

Procedure

Prepared as in Example 22b from N-(4-hydroxycyclohexyl)isobutyramide (Example 40c) and 2-amino-6-fluorobenzonitrile as an off-white solid (99%). MS 302 (MH+).

Sources & evidence

ORD record
ord-747c86d1fe224da592a890d2827bdfec
Source dataset
uspto-grants-2015_06
Patent number
US09049878B2

Reaction notes

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