Isopropylamine → 4-hydroxy-N-isopropylcyclohexanecarboxamide

HRID 2169904Notes

Reaction equation

[OH:1][CH:2]1[CH2:7][CH2:6][CH:5]([C:8]([OH:10])=O)[CH2:4][CH2:3]1.[CH3:11][CH:12]([NH2:14])[CH3:13]>>[OH:1][CH:2]1[CH2:3][CH2:4][CH:5]([C:8]([NH:14][CH:12]([CH3:13])[CH3:11])=[O:10])[CH2:6][CH2:7]1

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 1511384-Hydroxycyclohexanecarboxylic acid

Product 1

HCID 667468294-hydroxy-N-isopropylcyclohexanecarboxamide

Procedure

Prepared as in Example 24a from 4-hydroxycyclohexanecarboxylic acid and propan-2-amine as a colorless oil (68%). MS 186 (MH+).

Sources & evidence

ORD record: ord-d68cb02376a444568cd7e71811741341
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09049878B2

Reaction notes

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