2-Amino-6-fluorobenzonitrile → 3-(3-amino-2-cyanophenoxy)-N-(3-methoxybenzyl)-2,2-dimethylpropanamide

HRID 2169906Notes

Reaction equation

HRID 2169906 reaction equation
[OH:1][CH2:2][C:3]([CH3:17])([CH3:16])[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)=[O:5].[NH2:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23](F)[C:20]=1[C:21]#[N:22]>>[NH2:18][C:19]1[C:20]([C:21]#[N:22])=[C:23]([CH:24]=[CH:25][CH:26]=1)[O:1][CH2:2][C:3]([CH3:17])([CH3:16])[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)=[O:5]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 667461233-hydroxy-N-(3-methoxybenzyl)-2,2-dimethylpropanamide

Product 1

HCID 667469703-(3-amino-2-cyanophenoxy)-N-(3-methoxybenzyl)-2,2-dimethylpropanamide

Procedure

Prepared as in Example 22b from 3-hydroxy-N-(3-methoxybenzyl)-2,2-dimethylpropanamide (Example 46c) and 2-amino-6-fluorobenzonitrile as a white solid (41%). MS 354 (MH+).

Sources & evidence

ORD record
ord-5552eb7c39ea4117b7a09df543ac4648
Source dataset
uspto-grants-2015_06
Patent number
US09049878B2

Reaction notes

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