HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dihydro-2H-1-benzopyran-4-amine → Ethyl 4-amino-5-(3-(chroman-4-ylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dihydro-2H-1-benzopyran-4-amine | HCID 4961957 | — |
| Reactant | 3-((4-Amino-3-(ethoxycarbonyl)-2-methylquinolin-5-yl)oxy)-2,2-dimethylpropanoic acid | HCID 66746878 | — |
| Product | Ethyl 4-amino-5-(3-(chroman-4-ylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylate | HCID 66747292 | — |
Reaction Steps
Prepared as in Example 24a from 3-((4-amino-3-(ethoxycarbonyl)-2-methylquinolin-5-yl)oxy)-2,2-dimethylpropanoic acid (Example 47b) and chroman-4-amine (Lu, Y. et al. PCT Int. Appl. 2008, WO 2008043019) as a brown solid (37%). MS 478 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09049878B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-644e305eb70644caa837c2eda02d7a70 |
| Source note | uspto-grants-2015_06 |