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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2169915Generated: November 1, 2026

1,4-Benzodioxane-6-carboxylic Acid → (S)-ethyl 4-amino-5-(2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)propoxy)-2-methylquinoline-3-carboxylate

https://huagongshe.com/reaction/2169915

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Benzodioxane-6-carboxylic AcidHCID 2758833—
Reactant(S)-ethyl 4-amino-5-(2-aminopropoxy)-2-methylquinoline-3-carboxylateHCID 86658188—
Product(S)-ethyl 4-amino-5-(2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)propoxy)-2-methylquinoline-3-carboxylateHCID 86658192—

Reaction Steps

Prepared as in Example 24a from (S)-ethyl 4-amino-5-(2-aminopropoxy)-2-methylquinoline-3-carboxylate (Example 26b) and 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid as brown solid. MS 466 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09049878B2
Source datasetuspto-grants-2015_06
ORD IDord-0736fe35db594204b9be42814f90b97b
Source noteuspto-grants-2015_06