HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (S)-4-Amino-N-(2-(4'-carbamoyl-3'-fluorobiphenyl-4-yl)-1-cyanoethyl)tetrahydro-2H-pyran-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (S)-tert-Butyl 4-(2-(4'-carbamoyl-3'-fluorobiphenyl-4-yl)-1-cyanoethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate | HCID 59568571 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (S)-4-Amino-N-(2-(4'-carbamoyl-3'-fluorobiphenyl-4-yl)-1-cyanoethyl)tetrahydro-2H-pyran-4-carboxamide | HCID 49783905 | 120.3% |
Reaction Steps
(S)-4-Amino-N-(2-(4′-carbamoyl-3′-fluorobiphenyl-4-yl)-1-cyanoethyl)tetrahydro-2H-pyran-4-carboxamide (Example 25, 212 mg) was suspended in acetonitrile (353 μL) and water (6.7 mL) and stirred under nitrogen at room temperature for 17.5 h. The solid was collected by filtration and dried under vacuum to give the titled compound as a solid (205 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193239B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-ea02762da3a74966b9ddbabea8e2bc1a |
| Source note | uspto-grants-2012_06 |