HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Hydroxyethoxy)-3-methoxybenzoic acid → (S)-ethyl 4-amino-5-(2-(4-(2-hydroxyethoxy)-3-methoxybenzamido)butoxy)-2-methylquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Hydroxyethoxy)-3-methoxybenzoic acid | HCID 24694069 | — |
| Reactant | (S)-ethyl 4-amino-5-(2-aminobutoxy)-2-methylquinoline-3-carboxylate | HCID 86658218 | — |
| Product | (S)-ethyl 4-amino-5-(2-(4-(2-hydroxyethoxy)-3-methoxybenzamido)butoxy)-2-methylquinoline-3-carboxylate | HCID 86658220 | — |
Reaction Steps
Prepared as in Example 24a from (5)-ethyl 4-amino-5-(2-aminobutoxy)-2-methylquinoline-3-carboxylate (Example 97b) and 4-(2-hydroxyethoxy)-3-methoxybenzoic acid (Uto, Y. et al. Bioorg. Med. Chem. Lett. 2009, 19, 4151.) as brown solid (38%). MS 512 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09049878B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-334eef736ec34bffa8ce00d0ec64438a |
| Source note | uspto-grants-2015_06 |