HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Hydroxypropoxy)-3-methoxybenzoic acid → (S)-ethyl 4-amino-5-(2-(4-(3-hydroxypropoxy)-3-methoxybenzamido)butoxy)-2-methylquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Hydroxypropoxy)-3-methoxybenzoic acid | HCID 10561191 | — |
| Reactant | (S)-ethyl 4-amino-5-(2-aminobutoxy)-2-methylquinoline-3-carboxylate | HCID 86658218 | — |
| Product | (S)-ethyl 4-amino-5-(2-(4-(3-hydroxypropoxy)-3-methoxybenzamido)butoxy)-2-methylquinoline-3-carboxylate | HCID 86658222 | — |
Reaction Steps
Prepared as in Example 24a from (S)-ethyl 4-amino-5-(2-aminobutoxy)-2-methylquinoline-3-carboxylate (Example 97b) and 4-(3-hydroxypropoxy)-3-methoxybenzoic acid (Baraldi, P. G. et al. J. Med. Chem. 1999, 42, 5131.) as brown solid (41%). MS 526 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09049878B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-e6411c0a8c3f472497b301358abb1a91 |
| Source note | uspto-grants-2015_06 |