Cyclohexanol, 2-methoxy- → 2-Amino-6-(2-methoxycyclohexyloxy)benzonitrile

HRID 2169956Notes

Reaction equation

HRID 2169956 reaction equation
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[OH:9].[NH2:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15](F)[C:12]=1[C:13]#[N:14]>>[NH2:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15]([O:9][CH:4]2[CH2:5][CH2:6][CH2:7][CH2:8][CH:3]2[O:2][CH3:1])[C:12]=1[C:13]#[N:14]

Participants

3

Reactant 2

HCID 102911Cyclohexanol, 2-methoxy-HCID 5226592-Amino-6-fluorobenzonitrile

Product 1

HCID 667466302-Amino-6-(2-methoxycyclohexyloxy)benzonitrile

Procedure

Prepared as in Example 22b from 2-methoxycyclohexanol and 2-amino-6-fluorobenzonitrile as a yellow oil (34%). MS 247 (MH+).

Sources & evidence

ORD record
ord-54e38152bfd14448944ca0a9814c31c2
Source dataset
uspto-grants-2015_06
Patent number
US09049878B2

Reaction notes

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