3-Hydroxybenzoic Acid → Ethyl 4-amino-5-((1-(3-hydroxybenzoyl)piperidin-3-yl)methoxy)-2-methylquinoline-3-carboxylate

HRID 2169957Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2169957
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][NH:16][CH2:15]2)[N:5]=[C:4]([CH3:20])[C:3]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22].[OH:26][C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=1)[C:30](O)=[O:31]>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][N:16]([C:30](=[O:31])[C:29]3[CH:33]=[CH:34][CH:35]=[C:27]([OH:26])[CH:28]=3)[CH2:15]2)[N:5]=[C:4]([CH3:20])[C:3]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22]

Komponenten

3

Edukt 2

HCID 74203-Hydroxybenzoic AcidHCID 66746012Ethyl 4-amino-2-methyl-5-(piperidin-3-ylmethoxy)quinoline-3-carboxylate

Produkt 1

HCID 66746557Ethyl 4-amino-5-((1-(3-hydroxybenzoyl)piperidin-3-yl)methoxy)-2-methylquinoline-3-carboxylate

Versuchsvorschrift

Prepared as in Example 24a from ethyl 4-amino-2-methyl-5-(piperidin-3-ylmethoxy)quinoline-3-carboxylate (Example 110b) and 3-hydroxybenzoic acid as a white solid (34%). MS 464 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-d9caa6e1a4d54624ba8a922a442c1bbc
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09049878B2

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