HCID 66745949, compound → HCID 66746220, compound

HRID 2169964Notes

Reaction equation

HRID 2169964 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:5]=[C:4]([CH2:20][C:21]([O:23]CC)=[O:22])[C:3]=1[C:26]([O:28]CC)=[O:27]>O>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:5]=[C:4]([CH2:20][C:21]([OH:23])=[O:22])[C:3]=1[C:26]([OH:28])=[O:27]

Participants

3

Reactant 1

HCID 66745949HCID 66745949, compound

Product 1

HCID 66746220HCID 66746220, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared as in Example 1 from ethyl 4-amino-5-(2-cyclohexylethyl)-2-(2-ethoxy-2-oxoethyl)quinoline-3-carboxylate (Example 113a) as an orange solid (69%). 1H NR (400 MHz, DMSO-d6) δ 0.89-0.92 (m, 2H), 1.14-1.29 (m, 4H), 1.44-1.49 (m, 2H), 1.56-1.66 (m, 4H), 1.73-1.76 (m, 1H), 3.15 (t, J=8.0 Hz, 2H), 3.70 (s, 2H), 7.09-7.11 (m, 1H), 7.38-7.42 (m, 1H), 7.46-7.51 (m, 2H). MS 338 (MH+—H2O).

Sources & evidence

ORD record
ord-4d2661a95ae64743aabe7eec636a4261
Source dataset
uspto-grants-2015_06
Patent number
US09049878B2

Reaction notes

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