Cyclohexanemethanol → HCID 24777419, compound

HRID 2169970Notes

Reaction equation

HRID 2169970 reaction equation
[CH:1]1([CH2:7][OH:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14](F)[C:11]=1[C:12]#[N:13]>>[NH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14]([O:8][CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[C:11]=1[C:12]#[N:13]

Participants

3

Reactant 2

HCID 7507CyclohexanemethanolHCID 5226592-Amino-6-fluorobenzonitrile

Product 1

HCID 24777419HCID 24777419, compound

Procedure

Prepared as in Example 22b from cyclohexylmethanol and 2-amino-6-fluorobenzonitrile as a colorless oil (50%). 1H NR (400 MHz, CDCl3) δ 1.07-1.09 (m, 2H), 1.28-1.32 (m, 3H), 1.75-1.90 (m, 6H), 3.79 (d, J=6.4 Hz, 2H), 4.37 (s, 2H), 6.20 (d, J=8.4 Hz, 1H), 6.28 (d, J=8.4 Hz, 1H), 7.19 (t, J=8.4 Hz, 1H). MS 231 (MH+).

Sources & evidence

ORD record
ord-0b15a7589abd4644ac66c69ca6bdf5d5
Source dataset
uspto-grants-2015_06
Patent number
US09049878B2

Reaction notes

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