HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetoacetate → ethyl 4-amino-2-methyl-5-((tetrahydro-2H-pyran-4-yl)oxy)quinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | 2-amino-6-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile | HCID 66745938 | — |
| Product | ethyl 4-amino-2-methyl-5-((tetrahydro-2H-pyran-4-yl)oxy)quinoline-3-carboxylate | HCID 66746015 | — |
Reaction Steps
Prepared as in Example 2a from 2-amino-6-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile (Example 118b) and ethyl 3-oxobutanoate as a pale yellow solid (51%). MS 331 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09049878B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-c1ef72d26ead458fa7b5e5c18ad5373c |
| Source note | uspto-grants-2015_06 |