Diclofenac → HCID 86595983, compound

HRID 2170009Notes

Reaction equation

HRID 2170009 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([NH:11][C:12]2[C:13]([Cl:19])=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:18])=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1.[OH-].[Na+].O.O.O.O.O.O.[Cl-].[Sr+2:29].[Cl-]>O.C(O)C.O>[Sr:29].[CH:1]1[CH:2]=[CH:3][C:4]([NH:11][C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1

Participants

6

Reactant 3

HCID 3033DiclofenacHCID 14798Sodium HydroxideHCID 610186810025-70-4

Product 1

HCID 86595983HCID 86595983, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 19096565Water ethanolSolvent

Procedure

Diclofenac (0.35 g, 1.18 mmol) was dissolved in water/ethanol (30 ml, 50:50 (volume)) containing sodium hydroxide (24 mg, 0.59 mmol). A solution of strontium chloride hexahydrate (0.16 g, 0.59 mmol) in water (3 ml) was added. The mixture was stirred for 20 minutes, and the title compound was isolated by filtration and dried. Yield 0.122 g (15%).

Sources & evidence

ORD record
ord-2c00fd3408e94559b1aa77ec05525baa
Source dataset
uspto-grants-2015_06
Patent number
US09050312B2

Reaction notes

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