Trifluoroacetic acid → HCID 78323679, compound

Participants

Reaction Steps

N-(tert-Butyl)-4-(5-phenyl-4-((pyridin-2-ylmethyl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thiazole-2-sulfonamide (40.0 mg, 0.0770 mmol) and TFA (3 mL) were stirred at ambient temperature for 14 h. The excess TFA was evaporated under reduced pressure and the residue purified by preparative HPLC (Condition B-33 as described in general methods) to obtain 4-(5-phenyl-4-((pyridin-2-ylmethyl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thiazole-2-sulfonamide (9.00 mg, 26.0%). LCMS Condition B-13: retention time 1.94 min, [M+1]=464.0. HPLC Condition B-32: retention time 7.06 min, Purity 97.62%. 1H NMR (400 MHz, DMSO-d6): δ ppm 4.91 (d, J=4.4 Hz, 2H), 6.82 (d, J=2.8 Hz, 1H), 7.27-7.31 (m, 2H), 7.43-7.61 (m, 6H), 7.79 (dt, J=2.0 Hz, J=8.0 Hz, 1H), 7.90 (d, J=2.8 Hz, 1H), 8.24 (s, 2H), 8.39-8.40 (m, 1H), 8.63 (s, 1H).

Provenance & Evidence