HCID 90386097, compound → HCID 78324271, compound

Participants

Reaction Conditions

Reaction Steps

N-Benzyl-2-(5-(2,2-dimethyl-1,3-dioxolan-4-yl)pyridin-3-yl)-5-phenylpyrrolo[2,1-f][1,2,4]triazin-4-amine (0.150 g, 0.314 mmol) was dissolved in TFA (10 mL) and stirred for 1 h at 60° C. TFA was removed under reduced pressure and the reaction mixture was diluted with saturated sodium bicarbonate (100 mL) and extracted with ethyl acetate (3×30 mL). The combined organic extracts were dried over sodium sulfate, filtered and evaporated under reduced pressure to a residue which was purified by preparative HPLC (Condition B-53 as described in general methods) to get 1-(5-(4-(benzylamino)-5-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)pyridin-3-yl)ethane-1,2-diol (90.0 mg, 65.5%). The enantiomers of 1-(5-(4-(benzylamino)-5-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl)pyridin-3-yl)ethane-1,2-diol were separated by SFC (Condition B-52 as described in general methods).

Provenance & Evidence