Lithium iodide → HCID 90386936, compound

Participants

Reaction Steps

A mixture of Example 44c (0.0816 g, 0.162 mmol) and lithium iodide (0.65 g, 4.85 mmol) in pyridine (1 mL) was heated at 160° C. for 1 hour in a Biotage microwave reactor. The reaction mixture was partitioned between ethyl acetate and water, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography (silica gel, 20-80% ethyl acetate in heptanes) to provide 0.034 g (43%) of the title compound.

Provenance & Evidence