Phenol → HCID 86704948, compound

Participants

Reaction Conditions

Reaction Steps

2-Bromo-1-fluoro-4-nitrobenzene (2.5 g, 11.4 mmol), phenol (1.28 g, 13.6 mmol), and cesium carbonate (4.44 g, 13.6 mmol) were combined in dimethyl sulfoxide (140 mL) and heated at 110° C. for 1 hour. The reaction mixture was partitioned between ethyl acetate and saturated aqueous sodium chloride. The combined organics were washed with saturated aqueous sodium chloride, dried (anhydrous magnesium sulfate), filtered, and concentrated to afford the title compound.

Provenance & Evidence