HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 131726502, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2-{[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3h-benzoimidazole-5-carbonyl]-aminooxy}-ethyl)-methyl-carbamic acid tert-butyl ester | HCID 87688601 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131726502 | HCID 131726502 | — |
Reaction Steps
Prepared from (2-{[6-(4-bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carbonyl]-aminooxy}-ethyl)-methyl-carbamic acid tert-butyl ester 29ww by trifluoroacetic acid deprotection in methylene chloride. MS APCI (+) m/z 470, 472 (M+, Br pattern) detected; 1H NMR (400 MHz, CD3OD) δ 8.31 (s, 1H), 7.74 (s, 1H), 7.51 (d, 1H), 7.19 (dd, 1H), 6.39 (dd, 1H), 4.11 (m, 2H), 3.97 (s, 3H), 3.12 (m, 2H), 2.72 (s, 3H); 19F NMR (376 MHz, CD3OD) −77.41 (s, 3F), −134.79 (s, 1F).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193231B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-0f079af44c644728852becd4e125e189 |
| Source note | uspto-grants-2012_06 |