反应详情

To a solution of 3-methoxy-4-methylphenylacetonitrile (2.0 g, 12.4 mmol) in dry CH2Cl2 (50 ml) cooled to −78° C., BBr3 1 M in CH2Cl2 (27 ml, 27 mmol) was added dropwise. The mixture was stirred overnight allowing the cooling bath to expire. The mixture was slowly poured in ice/water under stirring. When the ice melted, the aqueous phase was extracted with EtOAc and the organic phase was dried over Na2SO4, filtered and the solvent was evaporated under reduced pressure. The crude title compound (1.7 g, 93% yield) was used in the next step without further purification.

1. stirringunder stirring
2. extractionthe aqueous phase was extracted with EtOAc
3. dry with materialthe organic phase was dried over Na2SO4
4. filtrationfiltered
5. customthe solvent was evaporated under reduced pressure