Nitric Acid → 3-Hydroxyadamantane-1-carboxylic acid

Participants

Reaction Steps

The same operations as conducted in Example 1 were repeated, except that the reaction mixture temperature after dropwise addition of nitric acid was set to 50° C. In the first carboxylation reaction step, the conversion of 1-adamantanol was found to be 99.0% and 1-adamantane carboxylic acid was generated in a reaction yield of 97%. In the second oxidation reaction step, the conversion of 1-adamantane carboxylic acid was found to be 99% and white crystals of 3-hydroxy adamantane-1-carboxylic acid (28.3 g, yield: 75.2%) were obtained.

Provenance & Evidence