3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide → 3-(6-amino-2-(2-(3,5-difluorophenyl)-1-(2-(5-fluoro-1H-indol-3-yl)acetamido)ethyl)pyridin-3-yl)benzamide

Participants

Reaction Steps

The title compound was prepared according to the method presented for the synthesis of compound 1H of Example 1 utilizing 1G and 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide. 1H NMR (400 MHz, CDCl3) δ 8.06-7.95 (m, 4H), 7.50-7.38 (m, 2H), 7.26-7.20 (m, 1H), 7.13 (m, 1H), 6.89-6.81 (m, 3H), 6.60 (d, J=8.9 Hz, 1H), 6.50-6.39 (m, 2H), 6.07 (d, J=5.8 Hz, 2H), 5.43 (d, J=8.8 Hz, 1H), 3.59 (s, 2H), 2.88 (dd, J=13.6, 9.3 Hz, 1H), 2.76 (dd, J=13.7, 7.5 Hz, 1H). MS (m/z) 535.4 [M+H]+.

Provenance & Evidence