(S)-N-(1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide → (S)-N-(1-(5-bromo-2-((2-methoxyethyl)amino)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide

HRID 2170329Notes

Reaction equation

HRID 2170329 reaction equation
BrC1C([C@H](NC(=O)CN2C3CCCCC=3C(C(F)(F)F)=N2)CC2C=C(F)C=C(F)C=2)=NC([NH:8][CH2:9][CH2:10][O:11][CH3:12])=NC=1.[Br:40][C:41]1[C:42]([C@@H:51]([NH:61][C:62](=[O:80])[CH2:63][N:64]2[C:72]3[C:71]([F:74])([F:73])[CH2:70][CH2:69][C:68]([F:76])([F:75])[C:67]=3[C:66]([CH:77]([F:79])[F:78])=[N:65]2)[CH2:52][C:53]2[CH:58]=[C:57]([F:59])[CH:56]=[C:55]([F:60])[CH:54]=2)=[N:43][C:44](S(C)(=O)=O)=[N:45][CH:46]=1>>[Br:40][C:41]1[C:42]([C@@H:51]([NH:61][C:62](=[O:80])[CH2:63][N:64]2[C:72]3[C:71]([F:74])([F:73])[CH2:70][CH2:69][C:68]([F:76])([F:75])[C:67]=3[C:66]([CH:77]([F:79])[F:78])=[N:65]2)[CH2:52][C:53]2[CH:58]=[C:57]([F:59])[CH:56]=[C:55]([F:60])[CH:54]=2)=[N:43][C:44]([NH:8][CH2:9][CH2:10][O:11][CH3:12])=[N:45][CH:46]=1

Participants

3

Reactant 2

HCID 90281385(S)-N-(1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamideHCID 90281480(R)-N-(1-(5-bromo-2-((2-methoxyethyl)amino)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide

Product 1

HCID 90281357(S)-N-(1-(5-bromo-2-((2-methoxyethyl)amino)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide

Procedure

The title compound (12D) was prepared according to the method presented for the synthesis of compound 11I of Example 11 utilizing 12C. MS (m/z) 671.34 [M+H]+.

Sources & evidence

ORD record
ord-24ded9d33d7040f0ad120c45abc6a55c
Source dataset
uspto-grants-2015_06
Patent number
US09050344B2

Reaction notes

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