HRID2170331

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75646

Cyclopropanemethanamine

C4H9N

结构：CS(=O)(=O)c1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1

HCID90281385

未命名化合物

结构：COCCNc1ncc(Br)c([C@@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2CCCC3)n1

HCID90281480

未命名化合物

PRODUCTS

生成物

结构：O=C(Cn1nc(C(F)F)c2c1C(F)(F)CCC2(F)F)N[C@@H](Cc1cc(F)cc(F)c1)c1nc(NCC2CC2)ncc1Br

HCID90281571

未命名化合物

PROCEDURE

实验过程

The title compound (13A) was prepared according to the method presented for the synthesis of compound 11I of Example 11 utilizing cyclopropylmethanamine and 12C. MS (m/z) 668.95 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-430632d14fd5415181d0c797132892b8
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09050344B2
来源说明: uspto-grants-2015_06

反应 SMILES

BrC1C([C@H](NC(=O)CN2C3CCCCC=3C(C(F)(F)F)=N2)CC2C=C(F)C=C(F)C=2)=NC(NCCOC)=NC=1.[CH:40]1([CH2:43][NH2:44])[CH2:42][CH2:41]1.[Br:45][C:46]1[C:47]([C@@H:56]([NH:66][C:67](=[O:85])[CH2:68][N:69]2[C:77]3[C:76]([F:79])([F:78])[CH2:75][CH2:74][C:73]([F:81])([F:80])[C:72]=3[C:71]([CH:82]([F:84])[F:83])=[N:70]2)[CH2:57][C:58]2[CH:63]=[C:62]([F:64])[CH:61]=[C:60]([F:65])[CH:59]=2)=[N:48][C:49](S(C)(=O)=O)=[N:50][CH:51]=1>>[Br:45][C:46]1[C:47]([C@@H:56]([NH:66][C:67](=[O:85])[CH2:68][N:69]2[C:77]3[C:76]([F:78])([F:79])[CH2:75][CH2:74][C:73]([F:80])([F:81])[C:72]=3[C:71]([CH:82]([F:84])[F:83])=[N:70]2)[CH2:57][C:58]2[CH:59]=[C:60]([F:65])[CH:61]=[C:62]([F:64])[CH:63]=2)=[N:48][C:49]([NH:44][CH2:43][CH:40]2[CH2:42][CH2:41]2)=[N:50][CH:51]=1