HRID2170340

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67435

1,4-Dioxa-8-azaspiro(4.5)decane

C7H13NO2

结构：CS(=O)(=O)c1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1

HCID90281385

未命名化合物

结构：CNc1ncc(Br)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)CCC3(F)F)n1

HCID90281536

未命名化合物

PRODUCTS

生成物

结构：O=C(Cn1nc(C(F)F)c2c1C(F)(F)CCC2(F)F)N[C@@H](Cc1cc(F)cc(F)c1)c1nc(N2CCC3(CC2)OCCO3)ncc1Br

HCID90281216

未命名化合物

PROCEDURE

实验过程

The title compound (19A) was prepared according to the method presented for the synthesis of compound 14A of Example 14 utilizing 12C and 1,4-dioxa-8-azaspiro[4.5]decane. MS (m/z) 740.04 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-44c7694bf8f84655a75f7139b314669c
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09050344B2
来源说明: uspto-grants-2015_06

反应 SMILES

[Br:1][C:2]1[C:3]([C@@H:10]([NH:20][C:21](=[O:39])[CH2:22][N:23]2[C:31]3[C:30]([F:33])([F:32])[CH2:29][CH2:28][C:27]([F:35])([F:34])[C:26]=3[C:25]([CH:36]([F:38])[F:37])=[N:24]2)[CH2:11][C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([F:19])[CH:13]=2)=[N:4][C:5]([NH:8][CH3:9])=[N:6][CH:7]=1.BrC1C([C@@H](NC(=O)CN2C3C(F)(F)CCC(F)(F)C=3C(C(F)F)=N2)CC2C=C(F)C=C(F)C=2)=NC(S(C)(=O)=O)=NC=1.[O:81]1[C:85]2([CH2:90]CN[CH2:87][CH2:86]2)[O:84][CH2:83][CH2:82]1>>[Br:1][C:2]1[C:3]([C@@H:10]([NH:20][C:21](=[O:39])[CH2:22][N:23]2[C:31]3[C:30]([F:33])([F:32])[CH2:29][CH2:28][C:27]([F:34])([F:35])[C:26]=3[C:25]([CH:36]([F:37])[F:38])=[N:24]2)[CH2:11][C:12]2[CH:13]=[C:14]([F:19])[CH:15]=[C:16]([F:18])[CH:17]=2)=[N:4][C:5]([N:8]2[CH2:87][CH2:86][C:85]3([O:84][CH2:83][CH2:82][O:81]3)[CH2:90][CH2:9]2)=[N:6][CH:7]=1