HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → HCID 90281418, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | HCID 90281331 | HCID 90281331 | — |
| Reactant | (S)-N-(1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide | HCID 90281385 | — |
| Product | HCID 90281418 | HCID 90281418 | — |
Reaction Steps
The title compound (26) was prepared according to the method presented for the synthesis of compound 14B of Example 14 starting with 2-aminoethanol and 12C. 1H NMR (400 MHz, CD3OD) δ 8.83 (d, J=7.7 Hz, 1H), 8.06 (s, 2H), 7.49-7.32 (m, 2H), 7.21 (dd, J=10.7, 8.5 Hz, 1H), 7.02-6.58 (m, 2H), 6.45 (d, J=6.1 Hz, 2H), 5.22 (m, 1H), 5.05 (s, 2H), 3.86-3.58 (m, 4H), 3.18-2.85 (m, 2H), 2.66-2.23 (m, 4H). MS (m/z) 716.23 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09050344B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-5ca650e677c747778459e2c40544e738 |
| Source note | uspto-grants-2015_06 |