HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-5-(2-(1-(2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-3-yl)-2-fluorobenzamide → (S)-5-(5-amino-2-(1-(2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-2-fluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-5-(2-(1-(2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-3-yl)-2-fluorobenzamide | HCID 90281315 | — |
| Reactant | 5-(2-((S)-1-(2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)-5-(1,3-dioxoisoindolin-2-yl)pyridin-3-yl)-2-fluorobenzamide | HCID 90281451 | — |
| Product | (S)-5-(5-amino-2-(1-(2-(3-(difluoromethyl)-4,4,7,7-tetrafluoro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamido)-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-2-fluorobenzamide | HCID 90281328 | — |
Reaction Steps
Compound 33 was prepared according to the method presented in the synthesis of Example 31 substituting compound 32 for compound 30K. 1H NMR (400 MHz, CD3OD) δ 8.08 (d, 1H), 7.39 (m, 2H), 7.28-7.17 (m, 1H), 7.14 (d, 1H), 7.00-6.60 (m, 2H), 6.37 (m, 2H), 5.19-5.01 (m, 3H), 3.12 (m, 1H), 2.99 (m, 1H), 2.66-2.34 (m, 4H). MS (m/z) 671.01 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09050344B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-576dad1c21f041b19d4fdad8a1e4c384 |
| Source note | uspto-grants-2015_06 |